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Neurosci Bull. 2013 Aug;29(4):436-44. doi: 10.1007/s12264-013-1365-4. Epub 2013 Jul 28.

Animal models of axon regeneration after spinal cord injury.

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  • 1Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, USA.

Abstract

With advances in genetic and imaging techniques, investigating axon regeneration after spinal cord injury in vivo is becoming more common in the literature. However, there are many issues to consider when using animal models of axon regeneration, including species, strains and injury models. No single particular model suits all types of experiments and each hypothesis being tested requires careful selection of the appropriate animal model. in this review, we describe several commonly-used animal models of axon regeneration in the spinal cord and discuss their advantages and disadvantages.

PMID:
23893429
[PubMed - indexed for MEDLINE]
PMCID:
PMC3920733
Free PMC Article
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