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Environ Toxicol Pharmacol. 2013 Sep;36(2):675-9. doi: 10.1016/j.etap.2013.06.014. Epub 2013 Jul 8.

Expedition of in vitro dissolution and in vivo pharmacokinetic profiling of sulfur nanoparticles based antimicrobials.

Author information

  • 1Biological Sciences Division, Indian Statistical Institute, 203 B.T. Road, Kolkata 700108, India. samratroychoudhury@gmail.com

Abstract

A comprehensive pharmacokinetic profiling of novel drugs and therapeutics is a definite prerequisite of drug discovery and development. The present study expedites the in vivo and in vitro pharmacokinetic properties of colloidal sulfur nanoparticles (SNPs). In vitro dissolution properties of SNPs have been demonstrated and compared with the in vivo pharmacokinetic parameters of rabbit (Oryctolagus cuniculus) serum sample. The present study was also aimed at developing levels of correlation between in vitro and in vivo pharmacokinetic parameters. Cumulative results of the proposed study also suggest good in vitro-in vivo correlation of these novel nanocolloids and suggest their immediate profiling as an antimicrobial drug.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

In vitro–in vivo pharmacokinetic profiling; Monoclinic; Orthorhombic; Sulfur nanoparticles

PMID:
23892072
[PubMed - indexed for MEDLINE]
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