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Lung Cancer. 2013 Sep;81(3):475-9. doi: 10.1016/j.lungcan.2013.07.001. Epub 2013 Jul 26.

Clinical significance of the frequency of regulatory T cells in regional lymph node lymphocytes as a prognostic factor for non-small-cell lung cancer.

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  • 1Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. hanagiri@med.uoeh-u.ac.jp

Abstract

BACKGROUND:

Regulatory T cells (Tregs) are potent immunosuppressive cells that play a crucial role in tumor immune escape. The purpose of the present study was to evaluate the prognostic significance of the frequency of CD4+CD25+Foxp3+ Tregs in the regional lymph node lymphocytes (RLNL) and peripheral blood lymphocytes (PBL) in patients who underwent surgical resection of non-small cell lung cancer (NSCLC).

METHODS:

The RLNL and PBL in 158 NSCLC patients who underwent complete surgical resection were collected at the time of surgery. The proportions of CD4+CD25+Foxp3+ cells in the RLNL and PBL were determined by flow cytometry.

RESULTS:

The average proportions of Tregs in the RLNL and PBL were 1.28% and 0.76%, respectively. The proportion of Tregs in the RLNL was significantly higher than that in the PBL (p < 0.0001). The 5-year overall survival rates of the patients according to the proportion of Tregs in the RLNL were 84.4% and 63.5% in the lower and higher groups, respectively. A significant difference was observed in the survival rate between the higher and lower groups (p = 0.0056). Among the patients with stage I disease, the 5-year survival rate (91.4%) was significantly higher in patients with the lower proportion of Tregs in RLNL that in the higher group (72.1%) (p = 0.0147).

CONCLUSIONS:

The higher proportion of Tregs in the RLNL was a significant unfavorable prognostic factor, even in patients with node-negative NSCLC. The information about the proportion of Tregs in the RLNL might improve the discriminatory power for assessing the risk of the recurrence of NSCLC.

Crown Copyright © 2013. Published by Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Foxp3; Immune escape mechanism; NSCLC; Regional lymph node lymphocytes; Regulatory T cells; Surgical resection

PMID:
23891508
[PubMed - indexed for MEDLINE]
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