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Bioorg Med Chem Lett. 2013 Sep 1;23(17):4862-6. doi: 10.1016/j.bmcl.2013.06.082. Epub 2013 Jul 3.

Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.

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  • 1Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

Abstract

Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Amine; Antibiotics; Cell division; DNA; Natural products

PMID:
23891184
[PubMed - indexed for MEDLINE]
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