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Bioorg Med Chem Lett. 2013 Sep 1;23(17):4806-12. doi: 10.1016/j.bmcl.2013.06.099. Epub 2013 Jul 10.

Semisynthesis and quantitative structure-activity relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents.

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  • 1Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People's Republic of China.

Abstract

In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, four series of novel cholesterol-based hydrazone derivatives were synthesized, and their insecticidal activity was tested against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1mg/mL. All the derivatives showed the better insecticidal activity than their precursor cholesterol. Quantitative structure-activity relationship (QSAR) model demonstrated that six descriptors such as RDF085v, Mor06u, Mor11u, Dv, HATS0v and H-046, are likely to influence the insecticidal activity of these compounds. Among them, two important ones are the Mor06u and RDF085v.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Botanical insecticide; Cholesterol; Insecticidal activity; Mythimna separata (Walker); QSAR; Structural modification

[PubMed - indexed for MEDLINE]
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