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Curr Opin Cell Biol. 2013 Dec;25(6):704-10. doi: 10.1016/ Epub 2013 Jul 24.

Dynamic regulation of ubiquitin-dependent cell cycle control.

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  • 1Department of Molecular and Cell Biology, University of California, Berkeley, United States.


Recent work revealed that cullin-RING ligases and the anaphase-promoting complex, two classes of ubiquitin ligases that are essential for cell division in all eukaryotes, are regulated in a highly dynamic manner. Here, we describe mechanisms that establish the dynamic regulation of these crucial ubiquitylation enzymes and discuss the functional consequences for cell division control.

Copyright © 2013. Published by Elsevier Ltd.

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