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Adv Cancer Res. 2013;120:113-34. doi: 10.1016/B978-0-12-401676-7.00004-8.

Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer.

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  • 1Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

Abstract

Since the initial discovery of AEG-1/MTDH/LYRIC, our appreciation for this novel protein's involvement in cancer has increased dramatically over the past few years. AEG-1/MTDH/LYRIC is a key functional target of the 8q22 genomic gain that is frequently observed in poor-prognosis breast cancer, where it plays a dual role in promoting chemoresistance and metastasis. Beyond this, growing evidence from clinical research indicates a strong correlation between AEG-1/MTDH/LYRIC expression and the pathogenesis of a large spectrum of cancer types, and multiple studies employing in vitro cell culture systems and in vivo xenograft models have revealed multifaceted roles of AEG-1/MTDH/LYRIC in cancer biology, including tumor cell proliferation, apoptosis, angiogenesis, and autophagy. With increasing mechanistic understanding of AEG-1/MTDH/LYRIC, discovery of agents that can block AEG-1/MTDH/LYRIC and its regulated pathways will be beneficial to cancer patients with aberrant expression of AEG-1/MTDH/LYRIC.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

AEG-1; Breast cancer; Chemoresistance; Metadherin; Metastasis

PMID:
23889989
[PubMed - indexed for MEDLINE]
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