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Allergy. 2013 Aug;68(8):1073-5. doi: 10.1111/all.12190. Epub 2013 Jul 29.

Increased circulating platelet microparticles as a potential biomarker in asthma.

Author information

  • 1Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Porto, Portugal. delfimd@med.up.pt

Abstract

BACKGROUND:

Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication.

METHODS:

In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects.

RESULTS:

Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117).

CONCLUSIONS:

We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

KEYWORDS:

VEGF; apoptosis; asthma; endothelial and platelet microparticles; sICAM-1

PMID:
23889600
[PubMed - indexed for MEDLINE]
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