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Neurol Int. 2013 Jun 25;5(2):23-7. doi: 10.4081/ni.2013.e8. Print 2013 Jun 25.

A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis.

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  • 1Department of Neurology, Ohda Municipal Hospital , Ohda.


We report the case of a 64-year old man who presented memory disturbance, low-grade fever, weight loss, and bilateral hand tremors for three months. He was diagnosed with non-herpetic acute limbic encephalitis (NHALE). Follow-up magnetic resonance imaging (MRI) revealed new lesions after symptomatic improvement following steroid pulse therapy. This may indicate that there is a time lag between the disturbance or recovery of neurons and astrocytes. Thus, other lesions might occasionally appear during convalescence in patients with NHALE, even if only minimal lesions were found on the initial MRI.


autoantibodies against glutamate receptors epsilon 2 and delta 2.; magnetic resonance imaging; non-herpetic acute limbic encephalitis; steroid pulse therapy

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