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J Diabetes Complications. 2014 May-Jun;28(3):311-5. doi: 10.1016/j.jdiacomp.2013.06.005. Epub 2013 Jul 23.

All-cause and cardiovascular mortality risk in U.S. adults with and without type 2 diabetes: Influence of physical activity, pharmacological treatment and glycemic control.

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  • 1School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3.
  • 2School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3. Electronic address: jennkuk@yorku.ca.

Abstract

AIMS:

This study determined the joint association between physical activity, pharmacotherapy, and HbA1c control on all-cause and cardiovascular disease (CVD) mortality risk in adults with and without type 2 diabetes (T2D).

METHODS:

12,060 adults from NHANES III and NHANES continuous (1999-2002) surveys were used. Cox proportional hazards analyses were included to estimate mortality risk according to physical activity, pharmacotherapy, and glycemic control (HbA1c <7.0%) status, with physically active, treated and controlled (goal situation) as the referent.

RESULTS:

Compared to the referent, adults with T2D who were uncontrolled, or controlled but physically inactive had a higher all-cause mortality risk (p<0.05). Compared to the referent, only adults with T2D who were physically inactive had a higher CVD mortality risk, regardless of treatment or control status (p<0.05). Normoglycemic adults had a similar all-cause and CVD mortality risk as the referent (p>0.05).

CONCLUSIONS:

Physical activity and glycemic control are both associated with lower all-cause and CVD mortality risk in adults with T2D. Adults with T2D who are physically active, pharmacologically treated, and obtain glycemic control may attain similar mortality risk as normoglycemic adults.

© 2014.

KEYWORDS:

HbA1c; Leisure Activities; NHANES; Type 2 diabetes mellitus

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