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Clin J Am Soc Nephrol. 2013 Nov;8(11):1979-87. doi: 10.2215/CJN.03400313. Epub 2013 Jul 25.

A patient with nephrotic-range proteinuria and focal global glomerulosclerosis.

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  • Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota.


A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecular weight proteins. The case illustrates the crucial role of electron microscopy as well as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.

[PubMed - indexed for MEDLINE]
[Available on 2014/11/7]
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