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J Am Coll Nutr. 2013;32(3):194-9. doi: 10.1080/07315724.2013.791147.

Lignan content of the flaxseed influences its biological effects in healthy men and women.

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  • 1Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis, Davis, California, USA.

Abstract

OBJECTIVE:

The omega-3 polyunsaturated fatty acid (n-3 PUFA) as well as lignan components of flaxseed (FLX) can have beneficial effects. In this 6-week-long, randomized, double-blinded, placebo-controlled study, we investigated the effects of FLX lignans on cardiovascular risk factors.

METHODS:

Thirty-seven subjects (13 men and 24 women, age: 54±7 years, body mass index [BMI]: 29.7±1 kg/m2) consumed nutrition bars with similar macronutrient contents. The fatty acid composition and the lignan contents of the bars differed significantly. Two FLX bars both contained 3.0 g of alpha linolenic acid (ALA: 18:3 n-3) but different amount of lignans (0.15 g vs. 0.41 g).

RESULTS:

High-lignan FLX decreased total cholesterol (C) by 12% (p=0.044), LDL-C by 15% (p=0.022), and oxidized (Ox)-LDL by 25% (p=0.035). Regular FLX tended to increase Ox-LDL by 13% (p=0.051). The difference between the effects of high-lignan vs. regular lignan FLX on Ox-LDL was highly significant (p=0.004).

CONCLUSION:

High-lignan FLX has the unique property of decreasing Ox-LDL, which is an independent risk factor for cardiovascular disease.

PMID:
23885993
[PubMed - indexed for MEDLINE]
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