Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Obstet Gynecol. 2013 Aug;122(2 Pt 2):503-5. doi: 10.1097/AOG.0b013e31828b2f5c.

Vitamin K deficiency bleeding and early infant male circumcision in Africa.

Author information

  • 1Division of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. rplank@partners.org



Early infant (1-60 days of life) male circumcision is being trialed in Africa as a human immunodeficiency virus prevention strategy. Postcircumcision bleeding is particularly concerning where most infants are breastfed, and thus these infants are at increased risk of vitamin K deficiency bleeding.


During a circumcision trial, one infant bled for 90 minutes postprocedure. After discovering he had not received standard prophylactic vitamin K, we gave 2 mg phytomenadione (vitamin K1) intramuscularly; bleeding stopped within 30 minutes.


Vitamin K's extremely rapid action is not commonly appreciated. Neonatal vitamin K has been shown to be cost-effective. To increase availability and promote awareness of its importance, especially in low-resource settings where blood products and transfusions are limited, vitamin K should be included in the World Health Organization's Model List of Essential Medicines for Children.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk