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Neurosci Lett. 2013 Sep 13;551:58-61. doi: 10.1016/j.neulet.2013.07.017. Epub 2013 Jul 21.

Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population.

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  • 1Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.


GRIN1 is a gene that encodes the N-methyl-d aspartate (NMDA) receptor subunit1 (NR1). Variations of GRIN1 have been identified as a risk factor for schizophrenia and drug dependence, supporting hypotheses of glutamatergic dysfunction in these disorders. Methamphetamine (METH) is a psychostimulant drug which can induce psychotic symptoms reminiscent of those found in schizophrenia; thus GRIN1 is a candidate gene for vulnerability to METH dependence or METH-dependent psychosis. The present study examined two polymorphisms of GRIN1, rs11146020 (G1001C) and rs1126442 (G2108A), in 100 male Thai METH-dependent patients and 103 healthy controls using PCR-RFLP techniques. Neither polymorphism was significantly associated with METH dependence, although rs1126442 was highly significantly associated with METH-dependent psychosis, in which the A allele showed reduced frequency (P<0.00001). The present findings indicate that the rs1126442 of GRIN1 contributes to the genetic vulnerability to psychosis in METH-dependent subjects in the Thai population.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.


GRIN1; Methamphetamine; Pharmacogenetics; Psychosis; Substance misuse

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