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Obstet Gynecol Int. 2013;2013:757249. doi: 10.1155/2013/757249. Epub 2013 Jun 25.

Management of early stage, high-risk endometrial carcinoma: preoperative and surgical considerations.

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  • 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.


Endometrial cancer is the most common gynecologic malignancy in the developed world. Most cases are diagnosed at an early stage and have low-grade histology, portending an overall excellent prognosis. There exists a subgroup of patients with early, high-risk disease, whose management remains controversial, as current data is clouded by inclusion of early stage tumors with different high-risk features for recurrence, unstandardized protocols for surgical staging, and an evolving staging system by which we are grouping these patients. Here, we present preoperative and intraoperative considerations that should be taken into account when planning surgical management for this population of patients.

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