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The gene encoding L1, a neural adhesion molecule of the immunoglobulin family, is located on the X chromosome in mouse and man.
CIML INSERM-CNRS, Marseille, France.
The murine and human genes for the L1 neural adhesion molecule were shown to lie on conserved regions of the X chromosome to which genes responsible for several neuromuscular diseases have been mapped and which are adjacent to the fragile site (FRAXA) associated with mental retardation. By pulsed-field gel mapping we have demonstrated physical linkage between the L1 gene and other genes located in Xq28: L1 lies between the eye pigment RCP, GCP locus and the glucose-6-phosphate dehydrogenase (G6PD) gene. This location is compatible with the implication of the L1 molecule in one of the X-linked neuromuscular diseases mapped to this region.
PMID: 2387585 [PubMed - indexed for MEDLINE]
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Cited by 9 PubMed Central articles
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Cell adhesion molecule L1 in folded (horseshoe) and extended conformations.
Schürmann G, Haspel J, Grumet M, Erickson HP.
Mol Biol Cell. 2001 Jun; 12(6):1765-73.
[Mol Biol Cell. 2001]
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Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders.
Bateman A, Jouet M, MacFarlane J, Du JS, Kenwrick S, Chothia C.
EMBO J. 1996 Nov 15; 15(22):6050-9.
[EMBO J. 1996]
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Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer.
Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ.
J Cell Biol. 1994 Dec; 127(6 Pt 2):2009-20.
[J Cell Biol. 1994]
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