Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2013 Jul 9;8(7):e67763. doi: 10.1371/journal.pone.0067763. Print 2013.

Household transmission of rotavirus in a community with rotavirus vaccination in Quininde, Ecuador.

Author information

  • 1Division of Viral Diseases, Centers for Disease Control and Prevention; Atlanta, Georgia, United States of America. blopman@cdc.gov

Erratum in

  • PLoS One. 2013;8(9). doi:10.1371/annotation/b1efd2d1-cc25-44c8-99e1-4bcdd3b8ccc8.

Abstract

BACKGROUND:

We studied the transmission of rotavirus infection in households in peri-urban Ecuador in the vaccination era.

METHODS:

Stool samples were collected from household contacts of child rotavirus cases, diarrhea controls and healthy controls following presentation of the index child to health facilities. Rotavirus infection status of contacts was determined by RT-qPCR. We examined factors associated with transmissibility (index-case characteristics) and susceptibility (household-contact characteristics).

RESULTS:

Amongst cases, diarrhea controls and healthy control household contacts, infection attack rates (iAR) were 55%, 8% and 2%, (n = 137, 130, 137) respectively. iARs were higher from index cases with vomiting, and amongst siblings. Disease ARs were higher when the index child was <18 months and had vomiting, with household contact <10 years and those sharing a room with the index case being more susceptible. We found no evidence of asymptomatic infections leading to disease transmission.

CONCLUSION:

Transmission rates of rotavirus are high in households with an infected child, while background infections are rare. We have identified factors associated with transmission (vomiting/young age of index case) and susceptibility (young age/sharing a room/being a sibling of the index case). Vaccination may lead to indirect benefits by averting episodes or reducing symptoms in vaccinees.

PMID:
23874443
[PubMed - indexed for MEDLINE]
PMCID:
PMC3706538
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk