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J Asian Nat Prod Res. 2013;15(10):1123-9. doi: 10.1080/10286020.2013.817390. Epub 2013 Jul 22.

A new triterpenoid saponin from Ardisia gigantifolia.

Author information

  • 1a Department of Clinical Pharmacology , General Hospital of PLA , Beijing , 100853 , China.

Abstract

A new triterpenoid saponin, named 3-O-β-d-glucopyranosyl-(1 → 3)-β-d-xylopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 4)-[β-d-glucopyranosyl-(1 → 2)]-α-l-arabinopyranosyl-3β,16α,28,30-tetrahydroxy-olean-12-ene (1), along with four known triterpenoids (2-5), was isolated from the rhizomes of Ardisia gigantifolia. Their structures were elucidated by spectroscopic methods. Compounds 1-4 showed cytotoxic activity against Hela, EJ, BCG, and HepG-2 cell lines. The percentage of early apoptotic cells after treatment with 1 was significantly increased compared with control cells (p < 0.05).

PMID:
23869599
[PubMed - indexed for MEDLINE]
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