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Diabetes. 2013 Dec;62(12):4179-83. doi: 10.2337/db13-0656. Epub 2013 Jul 17.

Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants.

Collaborators (1259)

Skyler JS, Anderson M, Bourcier K, Becker D, Bingley P, Blum J, Bosi E, Buckner J, Chase H, Clare-Salzler M, Colman P, DiMeglio L, Eisenbarth GS, Fathman C, Gitelman S, Goland R, Gottlieb P, Greenbaum C, Harrison L, Herold K, Insel R, Krischer JP, Mahon J, Marks J, Moran A, Palmer JP, Peakman M, Pugliese A, Raskin P, Roncarolo MG, Russell W, Savage P, Schatz D, Sherwin R, Siegelman M, Simell O, Thomas J, Trucco M, Wagner J, Wherrett D, Wilson DM, Winter W, Fradkin J, Leschek E, Spain L, Benoist C, Bluestone J, Brown D, Cowie C, Hering B, Jordan S, Kaufman FR, Lachin JM, Nanto-Salonen K, Nepom G, Orban T, Parkman R, Pescovitz M, Peyman J, Ridge J, Rodriguez H, Ziegler A, Skyler JS, Bourcier K, Greenbaum CJ, Krischer JP, Leschek E, Rafkin L, Savage P, Cowie C, Foulkes M, Krause H, Lachin JM, Malozowski S, Peyman J, Ridge J, Zafonte SJ, Skyler JS, Greenbaum CJ, Kenyon NS, Rafkin L, Santiago I, Sosenko JM, Krischer JP, Bundy B, Qesha A, Ritzie L, Abbondondolo M, Adams T, Alies P, Badias F, Beam C, Boonstra M, Boulware D, Cuthbertson D, Eberhard C, Ford J, Ginem J, Guillette H, Hays B, Henry M, Law P, Linton C, Liu S, Lloyd J, Muller S, O'Donnell R, Parrimon Y, Paulus K, Pilger J, Ramiro J, Roberts A, Sadler K, Terry A, Wootten M, Xu P, Young K, Bassi M, Freeman D, Granger M, Kieffer M, Nallamshetty L, Shor A, Lachin JM, Foulkes M, Harding P, Krause-Steinrauf H, McDonough S, McGee PF, Hess KO, Phoebus D, Quinlan S, Raiden E, Fradkin J, Leschek E, Savage P, Spain L, Blumberg E, Braun J, Laffel L, Naji A, Nerup J, Orchard T, Tsiatis A, Veatch R, Wallace D, Lernmark A, Lo B, Mitchell H, Steffes M, Zinman B, Loechelt B, Baden L, Green M, Weinberg A, Eisenbarth GS, Marcovina S, Palmer JP, Weinberg A, Winter W, Yu L, Babu S, Orban T, Gottlieb P, Greenbaum C, Krause-Steinrauf H, Lachin JM, Leschek E, Loechelt B, Parkman R, Rafkin L, Rigby A, Skyler JS, Spain L, Wagner J, Greenbaum C, Bollyky J, Sanda S, Tridgell D, McCulloch-Olson M, Vendettuoli H, Hefty D, Ramey M, Webber C, Kuhns K, Hilderman N, Dove A, Hammond M, Klein J, Batts E, Monzavi R, Halvorson M, Bock M, Fisher L, Jeandron D, Wood J, Kaufman FR, Goland R, Greenberg E, Gallagher MP, Trast J, Chan M, Rodriguez H, Pescovitz M, DiMeglio L, Christner L, Nicholson M, Mendez M, Orban T, Benoist C, Wolfsdorf J, Ricker A, Jalahej H, Conboy D, Farkas K, Kis J, Zhang H, Fay S, Wilson DM, Buckingham BA, Aye T, Esrey T, Soto A, Perry J, Baker B, Rigby A, Berry B, Gitelman SE, Rosenthal SM, Anderson M, Adi S, Breen K, Hamilton C, Gottlieb P, Chase H, Michels A, Kastelic W, Weiner L, Schatz D, Haller M, Clare-Salzler M, Cook R, Mancini D, Abraham A, Hicks E, Cole G, Marks JB, Pugliese A, Matheson D, Blaschke C, Arazo L, Cisneros M, Acosta B, Moran A, Nathan B, Wagner J, Boes MA, Gibson C, Finney L, Albright-Fischer T, Smith J, Becker D, Toledo F, Libman I, Riley K, Delallo K, Smith K, Gwynn D, Wohlers G, Raskin P, White P, Dickson B, Adhikari S, Siegelman M, Alford M, Torres N, Harden T, Pruneda L, Cordova E, Davis R, Fernandez S, Arthur J, Wherrett D, Eisel LA, Ahenkorah B, Razack N, Sriskandarajah M, Russell WE, Thomas JW, Moore DJ, Brown A, Black M, Pittel E, Brendle F, Bosi E, Battaglia M, Belloni C, Bianconi E, Falqui L, Grogan P, Lombardoni C, Grogan SM, Bingley P, Aitken R, Castleden H, Farthing N, Matthews C, McGee J, Wheaton C, Harrison LC, Andaloro E, Breen C, Colman P, Fourlanos S, Gellert S, Healy F, Wentworth J, Simell OG, Jokipuu S, Kallio T, Mantymaki E, Nanto-Salonen K, Niininen T, Nurmi B, Romo M, Ruohonen E, Sarma M, Simell T, Suomenrinne S, Torma M, Skyler JS, Brown D, Chase H, Davis B, Collier E, Cowie C, Eisenbarth GS, Davis B, Fradkin J, Grave G, Greenbaum C, Jackson RA, Kaufman FR, Krischer JP, Marks JB, Palmer JP, Ricker A, Schatz DA, Wilson D, Winter WE, Wolfsdorf J, Zeidler A, Dickler H, Eastman RC, Maclaren NK, Malone JI, Robertson R, Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase H, Leschek E, Palmer JP, Chase H, Cowie C, Fradkin J, Eisenbarth GS, Greenbaum C, Herold K, Kaufman FR, Krischer JP, Marks JB, Rafkin-Mervis LE, Schatz DA, Skyler JS, Aneju B, Conboy D, Cook R, Dennis MA, Finney L, Harris S, Davis B, Matheson D, McCulloch-Olsen M, Smith T, Valenzuela J, Vega N, Crofford OB, DeMets D, Lachin JM, Nerup J, Rossini A, Schiffrin A, Steffes M, Tsiatis A, Zinman B, Haider A, Haas J, Busch R, Marshilok K, Toleno N, Schade D, Katz P, Hornbeck D, Foster S, Roberts W, Vercher M, Foster C, Bower C, Hansen I, Burcell D, Anderson S, Shultz R, Sparks C, Wray J, Goldman L, Holt R, Counts D, Ostrowski D, Plotnick L, Fechner P, Donnelly C, Bourgeios P, Prosser P, Bowden B, Gunville F, McClave C, Heldt P, Ovalle F, Atchison J, Trull P, Bottomlee A, Betting S, Davis T, Wetzstein J, Clinkingbeard C, Davis J, Roosevelt T, Shamoon H, Duffy H, Anhalt H, Brussard L, Capotorto J, Sheehan P, Quyyumi S, Cohen N, Recker B, Castells S, Bastian W, AvRuskin T, Verdia V, Quattrin T, Dwigun K, Cefalu W, Clark N, Tilton L, Corenblum B, Harries S, Whitty A, McInroy R, Smith S, Willi S, Key L Jr, O'Rear D, Willi S, O'Rear D, Grubb S, Taylor K, Adams P, Reeves M, Reeves P, Marshall R, Tessmann E, Dwarakanathan A, Beebe C, Weintraub-Yohay I, O'Donnell P, Rich B, Imperial J, Silverman B, Edidin D, Goodman S, Brodsky I, Brodsky L, Klein D, Dolan L, Standiford D, Rogers D, Switzer C, Goldstein D, Eichelberger D, Smith A, Ganong C, Zipf W, Dyas M, Sotos J, Young C, Christi C, Riley W, Salai S, Raskin P, Marks J, Alford M, Sachson R, Lebowitz C, Cook J, Stedman J, Indra D, Gutai J, Vinuya B, McGraw-Maly M, Feng W, Williams C, Krygsman C, Pierce M, Freemark M, Litton J, Ryan E, Todd K, Aboud D, Pacillas M, Hines J, Walczak A, Aparicio L, Harbaugh D, Bergeson M, Rozell M, Mahan E, Brooks H, Ginier P, Hensley P, Ellyn G, Heymann M, Johnson B, Tack J, Sondrol L, Hjelle T, Perry D, Albert J, Flory L, Gerrity N, Naab C, Heck J, Weber S, Mulhall P, Lansden B, Cummings E, Salisbury S, Armour C, Ratzan S, Trahiotis M, Nemery R, Carney H, Shorkey D, Fitz-Patrick D, Taniguchi A, Gunn S, Copeland K, McGirk S, Liljenquist J, Fielding C, Richards S, Best V, Rodriguez H, Freidenberg G, Amstutz L, Weir C, Tsalikian E, Hoffman R, Bayless M, Hare J, Hare K, Kyner J, Eaks G, Howard C, Moore W, Woodford B, Salyer T, Wannarachue N, Meridith R, Squires D, Deubler D, Bruschetta H, Nickels D, Dothard C, Courtney A, Marcus A, Beisswenger J, Kairys S, Boyle W, Christiano A, O'Dell R, Touchette A, Thrailkill K, Karounos D, Webb S, Moore L, Allweiss P, Anderson F, Mahon J, McCallum J, Raffel L, Rotter J, Verne A, Davidson M, Keppler G, Banerjee S, Simon M, MacDonald M, Mokrohisky S, Speiser P, Fort P, Corrigan J, Pelkola S, Kitabchi A, Murphy M, Lambeth H, Burghen G, McGlendon P, Bondani J, LeNoye P, Alemzadeh R, Koppen M, Canas J, Lamerson M, Spencer M, Etzwiler D, Reynolds K, Eyler N, Allen P, Warner B, Rettig K, Levens K, Davis M, Polychronakos C, Laforte D, Zeller W, McKernan J, Finn S, Powers A, Lipps J, Raghavan S, Broadstone V, Raake P, Weissberg K, Tamborlane W, Gatcomb P, Blonde L, Zimmerman T, Zimmerman R, Liebel C, Chalew S, Vargas A, Rao J, Ascani J, Compton T, Cerame B, Harbison M, Newfield R, New M, Wajnrajch M, Vargas I, Herold K, Schachner H, Feberes G, Maclaren N, Golub D, Rappaport R, McEvoy R, Thomas, Pi-Sunyer X, Saltiel-Berzin R, Rappaport R, Koblish J, Blackett P, Comp C, Beck J, Hassing J, Hahn L, Lane J, Corley K, Larson L, Fiallo-Sharer R, Lee P, Cortez A, Varni N, Speer H, Crockett S, McDaniel W, Roberts V, Weinzimer S, Cohen P, Baker L, De Paul D, Rebecca E, Dolinar R, Block M, Krametbauer P, Frazer T, Veray G, Ahmann A, LaFranchi S, Jennings P, Kelleher A, Kummer M, Hansen J, Hunter M, LaMorticella K, Eckert K, Klaff L, Brazg R, Springs J, Wilson B, Isaacson E, Kuhn H, Willis D, Kaplowitz P, Genther K, Bourdony C Jr, Rivera A, Basu R, Rizza R, Whannel P, Jospe N, Utzman A, Sheikholisham B, Hiner C, Hardin D, Lindsay R, Swinyard M, Rallison M, Jarrett L, Sirstins J, Pierson K, Trevino S, Schwartz S, Dickens K, Clark S, Scroggin P, Greene G, Linarelli L, Camuro E, Hermosillo S, Estrada R, Bailey W, Fuqua J, Gitelman S, Fountaine M, Colon G, de Pijem L, Nieves-Rivera F, Rivera A, Perez R, Jovanovic L, Vesterfelt S, Saenz C, Kletter G, Pihoker K, Kearns S, Keppen L, Johnson P, Krell E, Duck S, Noble M, Thompson S, Wilson K, Soler N, McCall L, Allen H, Roumeliotis G, Chase L, Braden-Moll D, White N, Levandoski L, Malone J, Steinbrueck J, Ulbrecht J, Lambert N, Mulhall P, Wilson T, Lane A, Smaldone A, Modilevsky T, Izquierdo R, Weinstock R, Mackowiak S, Brindak K, Wherrett D, Daneman D, Pearlman K, McLellan C, Rogers A, Ipp E, Mao C, Rushovich E, Thorne I, Jelley D, Greer D, Metzger D, Austin A, Turek J, Archer J, Nunlee-BlaND G, Johnson K, Harris J, Driedbart S, Noto R, Romano A, Herl W, Guthrie R, Tatpati O, Brenner A, Lippert D, Reeves G, Swenson C, Murphy L, Dean H, Berard L, Werbel S, Bell-Farrow A, Mauseth R, Hanson J, Mishr S, DiCaria L, Wilson B, Wischmeier C, Moosa M, Levy R, Desemone J, Bentson L, Lando H, Hoelscher J, Biggs W, Carano R, Nostrand P, Achee L, Kelly J, Nolan P, Otsuka T, Heyrmann K, Autio N, Gohl K, Prendergast J, Delcher H, Reed C, Mellman M, Herskowitz I, Hoffman W, Naas M, Dubois S, Chaykin L, Pershadsingh H, Shah H, Ettinger V, Reiner B, McLaughlin J, Levin P, Boniface A, Leigh H, Ginsberg G, Weiss D, Rosecan M, Doyle P, McAfee J, Goldfogel G, Henschel J, Gorson D, Ramos J, Bush M, Martin K, Birch B, Reimer S, Neil J, Saenger P, Dimartino-Nardi J, Capotorto J, Sheehan P, Quyyumi S, Cohen N, Stein R, Klonoff D, de Souza J, McCarthy D, Salisbury J, Edstrom C, William MF, Brown M, Vigersky R, Smith C, Krishna A, Benson R, Murphy F, Pruchno C, Davenport M, Clarke W, McDuffie M, Melinkovich G, Bell V, Ravanam A, W W, Leonard D, Dahms W, Scott K, Bowyer F, Leichter S, Kaplan R, Lewis S, Miller R, Upmanyu M, Goldberg N, Savino R, Wentworth S, Langdon D, Weideman C, Urban M, Transue D, Whitehouse F, Cara J, Shaw S, Price W, Iverson R, Slag M, Hutt J, McLean N, Moore R, Christenson R, Valika K, Nayak N, Bloch C, Strom L, Bailey T, Varma C, Calder D, Bilger M, Larson K, Papenhausen M, Shlesinger Y, Kenien A, Wright E, Jabbar M, Lorber D, Berkett J, Robinson R, Kadambi A, Sullivan W, Meyer E, Bautista J, Norwood P, Biederman E, Nassberg S, Goscin L, Mata M, Thompson N, Harrell R, Cabral J, Pietri A, Scott C, Flannery T, Wilson D, Rogers B, Campos M, Montero M, Beals B, Mair D, Rood R, Taylor J, Sevier R, Harris G, Pfeifer M, Blechman M, Giangola J, Creech R, Lathrop M, Dunaif A, Miceli G, Lewy-Alterbaum L, Jellinger P, Novak S, Gellman K, Lerman S, Waxman S, Hamilton D, Driscoll H, Schneier R, Casey J, Boyce P, Meachum J, Milburn J, Pomeroy D, Moll G, Macyko K, Fox L, Mauras N, Ledereich P, Gill C, Rossetto B, Houlden R, Heck P, Korducki J, Winston J, Geffner D, Edelman S, Henry B, Einhorn D, Fink R, Leidlein J, Arul K, Henry D, Donaldson D, Middlestadt K, Grande-Luke L, Guest J, Wermers R, Bells B, Frindik P, Gewirtz G, Blyfeld C, Brakin M, Borut D, Geffner D, Winston J, Geffner M, Rodriguez M, Gura V, Rodriguez M, Shough C, Bays H, Varma S, Bourgeios M, Sloan L, Guthrow CE Jr, Shaw S, Ruby R, Motzkin-Kava B, Jebsen D, Zador I, Maby S, Crantz F, Zietlow D, Kudzma D, Levy E, Shapiro ET, Jacobi J, Abelove W, Perez-Rodriguez J, Gonzalez-Mendoza L, Richton S, Weissman P, Stein N, Sherman-Adcock L, Fergeson D, Jacobson M, Sennett J, Jain R, Etzwiler D, Ramsay R, Holland M, Carrington S, Seagraves S, Yue G, Downs-Colby J, Flores H, Weinrib S, Jones E, Starkman H, White D, Doberne L, Greenfield M, Alexander K, O'Sullivan C, Duncan R, Barandiaran G, Yunis J, Nunez L, Ramos V, Holland E, Balash W, Sher J, Agrin R, Frentz J, Fennoy I, Baron S, Door J, Vinik A, Savery F, Gareis F, Mack R, Devoe D, Fan Y, Domek D, Kelley D, Roberts T, Gutshall B, Madu I, Poucher R, Mengel M, Desrosiers P, Banks R, Kopp B, Fishman I, Geller D, Smith W, Duncan J, Nyman O, 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Abstract

We studied the change in the first-phase insulin response (FPIR) during the progression to type 1 diabetes (T1D). Seventy-four oral insulin trial progressors to T1D from the Diabetes Prevention Trial-Type 1 with at least one FPIR measurement after baseline and before diagnosis were studied. The FPIR was examined longitudinally in 26 progressors who had FPIR measurements during each of the 3 years before diagnosis. The association between the change from the baseline FPIR to the last FPIR and time to diagnosis was studied in the remainder (n = 48). The 74 progressors had lower baseline FPIR values than nonprogressors (n = 270), with adjustments made for age and BMI. In the longitudinal analysis of the 26 progressors, there was a greater decline in the FPIR from 1.5 to 0.5 years before diagnosis than from 2.5 to 1.5 years before diagnosis. This accelerated decline was also evident in a regression analysis of the 48 remaining progressors in whom the rate of decline became more marked with the approaching diagnosis. The patterns of decline were similar between the longitudinal and regression analyses. There is an acceleration of decline in the FPIR during the progression to T1D, which becomes especially marked between 1.5 and 0.5 years before diagnosis.

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