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Chemistry. 2013 Aug 26;19(35):11717-24. doi: 10.1002/chem.201301298. Epub 2013 Jul 16.

Light activation for the versatile and accurate kinetic analysis of disassembly of self-immolative spacers.

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  • 1Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248 Paris, France.

Abstract

Three procedures that rely on photoactivation are introduced to accurately analyze the disassembly kinetics of a collection of self-immolative spacer groups within the window 10(-2)-10(3) s. Our results are relevant for deriving quantitative structure-property relationships. In particular, we have been able to access 20 ms temporal resolution, which made possible the measurement of the shortest ever reported disassembly time for an activated self-immolative spacer.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

disassembly; fluorescence; kinetics; photochemistry; self-immolation

PMID:
23861286
[PubMed]
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