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Macromol Biosci. 2013 Oct;13(10):1308-13. doi: 10.1002/mabi.201300117. Epub 2013 Jul 16.

Calcium-mediated secondary cross-linking of bisphosphonated oligo(poly(ethylene glycol) fumarate) hydrogels.

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  • 1Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.


This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


bisphosphonates; calcium-binding; coordination bonds; hydrogels; metal-polymer complexes

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