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J Craniofac Surg. 2013 Jul;24(4):1469-72. doi: 10.1097/SCS.0b013e31829030ed.

Mandibular Ewing sarcoma with chromosomal translocation t(21;22)(q22;q12).

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  • 1Department of Oral and Maxillofacial Surgery, Yokohama City University Hospital, Yokohama, Kanagawa, Japan.


Ewing sarcoma (ES) is a primary bone malignant neoplasm and is the second most common primary malignancy of the bone found in childhood and adolescence after osteosarcoma. ES has an annual frequency in the population younger than 20 years of approximately 2.9 per million. ES occurs most frequently in the long bones of the extremities and pelvis and very rarely in the jaw. Recently, it was revealed that chromosomal translocation t(11;22)(q24;q12), which fuses the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11, occurs in most cases of ES. We report here a rare case of mandibular ES in a 10-year-old child with chromosomal translocation t(21;22)(q22;q12) in which the EWS gene is fused with the ERG gene on chromosome 21.

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