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Cancer Epidemiol. 2013 Oct;37(5):619-24. doi: 10.1016/j.canep.2013.06.005. Epub 2013 Jul 11.

No association between genetic variants in angiogenesis and inflammation pathway genes and breast cancer survival among Chinese women.

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  • 1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.



Angiogenesis and inflammation are implicated in breast cancer prognosis; however, the role of individual germline variation in related genes is unknown.


A two-stage candidate pathway association study was conducted among 6983 Chinese women. Stage 1 included 2884 women followed for a median of 5.7 years; Stage 2 included 4099 women followed for a median of 4.0 years. Cox proportional hazards regression was used to estimate the effects of genetic variants on disease-free survival (DFS) and overall survival (OS).


Stage 1 included genotyping of 506 variants in 22 genes; analysis was conducted for 370 common variants. Nominally significant associations with DFS and/or OS were found for 20 loci in ten genes in Stage 1; variants in 19 loci were successfully genotyped and evaluated in Stage 2. In analyses of both study stages combined, nominally significant associations were found for nine variants in seven genes; none of these associations surpassed a significance threshold level corrected for the total number of variants evaluated in this study.


No association with survival was found for 370 common variants in 22 angiogenesis and inflammation pathway genes among Chinese women with breast cancer.


Our data do not support a large role for common genetic variation in 22 genes in breast cancer prognosis; research on angiogenesis and inflammation genes should focus on common variation in other genes, rare host variants, or tumor alterations.

Copyright © 2013 Elsevier Ltd. All rights reserved.


Angiogenesis genes; Breast cancer survival; CCL2; CCL5; CCR2; COL18A1; Chinese women; DFS; DNA; ER; FGFR4; FLT1; Genetic variants; HER2; HIF1A; HPGD; IL10; IL1B; IL6; Inflammation pathway genes; KDR; MAF; MMP1; MMP13; MMP2; MMP3; MMP7; MMP9; OS; PLAU; POSTN; PR; PTGES; PTGIS; PTGS2; SBCS; SBCSS; SERPINE1; SWHS; Shanghai Breast Cancer Study; Shanghai Breast Cancer Survival Study; Shanghai Women's Health Study; TGFB1; THBS1; VEGFA; chemokine (C-C motif) ligand 2; chemokine (C-C motif) ligand 5; chemokine (C-C motif) receptor 2; collagen, type XVIII, alpha 1; deoxyribonucleic acid; disease-free survival; estrogen receptor; fibroblast growth factor receptor 4; fms-related tyrosine kinase 1; human epidermal growth factor receptor 2; hydroxyprostaglandin dehydrogenase; hypoxia inducible factor 1, alpha subunit; interleukin 1, beta; interleukin 10; interleukin 6; kb; kilobase; kinase insert domain receptor; matrix metallopeptidase 1; matrix metallopeptidase 13; matrix metallopeptidase 2; matrix metallopeptidase 3; matrix metallopeptidase 7; matrix metallopeptidase 9; minor allele frequency; overall survival; periostin, osteoblast specific factor; plasminogen activator, urokinase; progesterone receptor; prostaglandin E synthase; prostaglandin I2 synthase; prostaglandin-endoperoxide synthase 2; serpin peptidase inhibitor, clade E, member 1 (previously known as PAI1); thrombospondin 1; transforming growth factor, beta 1; vascular endothelial growth factor A

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