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Histol Histopathol. 2014 Jan;29(1):77-87. Epub 2013 Jul 12.

BCL10 expression and localization in ocular adnexa MALT lymphomas: a comparative cytogenetic and immunohistochemical study.

Author information

  • 1Pathology Unit, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy.
  • 2Pathology Unit, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. francesca.collina@virgilio.it.
  • 3Pathology Unit, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. annadechiara@hotmail.com.
  • 4SC. Hematology, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. g.corazzelli@istitutotumori.na.it.
  • 5Hematology Institute, "Federico II" University, Naples, Italy. aderenzo@unina.it.
  • 6SC. Hematology, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. f.russo@istitutotumori.na.it.
  • 7Pathology Unit, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. monicantile@libero.it.
  • 8Biomorphological and Functional Sciences Department, "Federico II" University, Naples, Italy. staibano@unina.it.
  • 9Ophthalmology Department, "Federico II" University, Naples, Italy. strianes@unina.it.
  • 10Ophthalmology Department, "Federico II" University, Naples, Italy. fausto.tranfa@unina.it.
  • 11Pathology Unit, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. gbotti1@alice.it.
  • 12Biomorphological and Functional Sciences Department, "Federico II" University, Naples, Italy. gaderosa@unina.it.
  • 13Pathology Unit, "Istituto Nazionale Tumori Fondazione Giovanni Pascale"-IRCCS, Naples, Italy. r.franco@istitutotumori.na.it.

Abstract

T(1;14) (p22;q32) involving BCL10 and IGH genes is a rare but recurrent chromosomal aberration in MALT-type lymphoma. It is rarely described in ocular adnexa B cell lymphomas, although nuclear BCL10 shuttling seems to be critical for disease progression in this district. We have evaluated the translocations MALT lymphoma-related in a series of 45 ocular adnexa cases, focusing in particular on their relation with BCL10 expression and its cellular topographic distribution. A prognostic tissue microarray (TMA) with ocular adnexa MALT lymphomas was designed. A study of BCL10 expression and its topographic distribution was performed through immunohistochemistry. In addition the assessment of t(14;18) (q32;q21), t(1;14) (p22;q32) and t(11;18) (q21;q21) was determined by Fluorescent In Situ Hybridization (FISH). Our series revealed t(14;18) (q32;q21) in 6/43 cases (14,3%). t(1;14) (p22;q32), never described in ocular adnexa MALT lymphomas, was observed in 3/31 (9,7%), two of which exhibited the gain of 3' upstream BCL10 gene signal (4%), whereas no case showed t(11;18) (q21;q21). Moreover, BCL10 expression was observed in 18/45 cases. In particular its nuclear expression was revealed in 12/45 cases, cytoplasmic expression in 5/45 and both cytoplasmic and nuclear expression in 1/45. Statistical analysis demonstrated that while BCL10 cytoplasmic expression is significantly related to the presence of the investigated chromosomal aberrations, in particular with t(14;18) (q32;q21), BCL10 nuclear shuttling does not show any correlation with these translocations. Our data support that BCL10 nuclear distribution is neither related to BCL10 rearrangement nor to other known translocations.

PMID:
23846624
[PubMed - in process]
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