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Cancer Cell. 2013 Jul 8;24(1):1-2. doi: 10.1016/j.ccr.2013.06.008.

BRAF: a driver of the serrated pathway in colon cancer.

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  • 1Division of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, 952 BRB, 421 Curie Boulevard, Philadelphia, PA 19104, USA. anil2@mail.med.upenn.edu

Abstract

In this issue of Cancer Cell, Rad and colleagues report findings that underscore the importance of oncogenic BRAF mutation coupled with microsatellite instability, p16Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development. These findings provide translational insights into potential therapeutic intervention for BRAF mutant colon cancers.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23845435
[PubMed - indexed for MEDLINE]
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