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Am J Cancer Res. 2013 Jun 20;3(3):240-50. Print 2013.

Mouse models for colorectal cancer.

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  • 1Department of Molecular and Comparative Pathobiology, The Johns Hopkins University Baltimore, MD 21205, USA.


Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States, with the number of affected people increasing. There are many risk factors that increase CRC risk, including family or personal history of CRC, smoking, consumption of red meat, obesity, and alcohol consumption. Conversely, increased screening, maintaining healthy body weight, not smoking, and limiting intake of red meat are all associated with reduced CRC morbidity and mortality. Mouse models of CRC were first used in 1928 and have played an important role in understanding CRC biology and treatment and have long been instrumental in clarifying the pathobiology of CRC formation and inhibition. This review focuses on advancements in modeling CRC in mice.


Apc; Colorectal cancer; FAP; HNPCC; human; mouse models; stem cells; tumorigenesis

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