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J Pediatr Gastroenterol Nutr. 2013 Dec;57(6):813-6. doi: 10.1097/MPG.0b013e3182a3202f.

Viral co-infections are common and are associated with higher bacterial burden in children with clostridium difficile infection.

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  • 1Departments of Pediatrics, Washington University School of Medicine, St Louis, MO.


Clostridium difficile infections in children are increasing. In this cohort study, we enrolled 62 children with diarrhea and C difficile. We performed polymerase chain reaction assays to detect viral agents of gastroenteritis and quantify C difficile burden. Fifteen (24%) children diagnosed as having C difficile infection had a concomitant viral co-infection. These patients tended to be younger and had a higher C difficile bacterial burden than children with no viral co-infections (median difference = 565,957 cfu/mL; P = 0.011), but were clinically indistinguishable. The contribution of viral co-infection to C difficile disease in children warrants future investigation.

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