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Phytochemistry. 2013 Nov;95:315-21. doi: 10.1016/j.phytochem.2013.06.015. Epub 2013 Jul 6.

Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum.

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  • 1School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan.

Abstract

Torvpregnanosides A and B, two pregnane glycosides, and torvoside Q, a 23-keto-spirostanol glycoside, along with twelve known steroidal saponins were isolated from aerial parts of Solanum torvum. Of the latter, four of the 23-hydroxy-spirostanol glycosides, and, a yamogenin glycoside, were in this plant discovered. All structures were identified from spectroscopic data, and all the compounds were tested for in vitro anti-neutrophilic inflammatory activity. Two compounds showed selective inhibition against elastase release and superoxide anion generation, respectively, by human neutrophils with IC50 values of 5.66 and 3.59 μM, while two others inhibited both inflammatory mediators with IC50 values of 0.66-3.49 μM. Structure-activity relationships are discussed.

Copyright © 2013. Published by Elsevier Ltd.

KEYWORDS:

Anti-neutrophilic inflammation; Solanaceae; Solanum torvum; Steroidal glycoside

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