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Am J Hosp Palliat Care. 2014 May;31(3):315-21. doi: 10.1177/1049909113494745. Epub 2013 Jul 8.

The role of analgesic adjustment strategies in achieving analgesic efficacy in opioid-tolerant hospice patients in China.

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  • 11Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.


Diverse strategies of analgesic adjustment are often, respectively, used to sustain analgesic efficiency for opioid-tolerant patients with different refractory factors of pain. In order to select effective analgesic adjustment strategy for hospice patient without knowing explicit causes of diminishing analgesic efficiency, a retrospective data of 743 patients among 3760 hospice patients were analyzed. The efficacy and adverse effects were not significantly different among analgesic adjustment strategies at each adjustment. Opioid duration was not associated with clinical characteristics. For opioid-tolerant hospice patients, the analgesic adjustment strategy can be selected for individual patient. After repeated analgesic adjustments, opioid tapering may also occur.


adjusted; analgesic; analgesic efficacy; diverse strategies; hospice patients; opioid tolerance

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