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Curr Opin Virol. 2013 Jun;3(3):316-21. doi: 10.1016/j.coviro.2013.05.008. Epub 2013 Jul 5.

To dream the impossible dream: universal influenza vaccination.

Author information

  • Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, United States. JYEWDELL@niaid.nih.gov

Abstract

Year in and year out, influenza viruses exact a deadly and expensive toll on humanity. Current vaccines simply do not keep pace with viral immune evasion, providing partial protection, at best, among various age groups. A quantum leap in understanding the basic principles of the adaptive and innate immune responses to influenza viruses offers the opportunity to develop vaccines that forestall, and potentially ultimately defeat, influenza virus antigenic variation.

Published by Elsevier B.V.

PMID:
23835048
[PubMed - indexed for MEDLINE]
PMCID:
PMC3713083
Free PMC Article
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