Send to:

Choose Destination
See comment in PubMed Commons below
J Card Fail. 2013 Jul;19(7):478-93. doi: 10.1016/j.cardfail.2013.05.007.

Review of vasodilators in acute decompensated heart failure: the old and the new.

Author information

  • 1Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.


Despite substantial improvements in treatment for chronic heart failure, morbidity and mortality for acute decompensated heart failure (ADHF) remain high. Treatment of ADHF is focused on controlling symptoms rather than improving long-term outcomes. The vasodilators nitroglycerin (NTG) and sodium nitroprusside (SNP) have been used in ADHF for decades, but, since the development of nesiritide 10 years ago, interest in new vasodilators has grown. Therapies that improve not only hemodynamics and symptoms but also long-term outcomes are in high demand, and numerous new vasodilatory agents have been investigated, including various natriuretic peptides, soluble guanylyl cyclase agents, renin-angiotensin-aldosterone system-modifying agents, and others. A review of the literature shows that few of them rise to the challenge set by NTG and SNP.

Copyright © 2013 Elsevier Inc. All rights reserved.


Nitroglycerin; natriuretic peptide; sodium nitroprusside

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk