Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Clin Pract. 2013 Sep;67(9):918-21. doi: 10.1111/ijcp.12184. Epub 2013 Jul 8.

Baclofen in the treatment of persistent hiccup: a case series.

Author information

  • 1Department of Internal Medicine, Catholic University of Rome, Italy.

Abstract

BACKGROUND:

Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.

AIM:

To test baclofen administration for the treatment of persistent hiccup.

METHOD:

We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.

RESULTS:

Hiccup stopped in all patients after a single administration of the drug.

CONCLUSIONS:

Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.

© 2013 John Wiley & Sons Ltd.

PMID:
23834241
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk