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J Midlife Health. 2013 Jan;4(1):22-6. doi: 10.4103/0976-7800.109630.

Effect of mifepristone (25 mg) in treatment of uterine myoma in perimenopausal woman.

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  • 1Department of Obstetrics and Gynaecology, Rural Institute of Medical Sciences and Research, Saifai, District- Etawah, Uttar Pradesh, India.

Abstract

OBJECTIVES:

To evaluate the effect of Mifepristone (25 mg) on symptomatic myoma in perimenopausal women.

STUDY DESIGN:

Open label clinical trial.

MATERIALS AND METHODS:

Ninety three perimenopausal women of age 35-50 years having symptomatic myoma were selected from Gynecology OPD and given 25 mg Mifepristone once daily continuously for three months. Variables as; baseline uterine size, uterine volume, myoma size, volume, their number, position, characteristics, hemoglobin and blood parameters, were taken and followed monthly for six months. Bleeding and pain scores were checked on monthly visits. Changes in above parameters were tabulated during the first three months treatment phase and then next three post-treatment phase for analysis.

STATISTICAL ANALYSIS:

Was done by calculating mean, standard deviation, standard error and percentage distribution of variables.

RESULTS:

Menorrhagia was the most common symptom which led patients to report to hospital. Mean uterine volume reduced to 63.69% of baseline, Mean dominant Myoma volume reduced to 53.62% and hemoglobin level raised to 137% after complete three months of treatment. Changes persisted in next three months post-treatment follow-up, while hysterectomy was required in 10 (12.2%) cases.

CONCLUSION:

Three months treatment of 25 mg Mifepristone effectively controls bleeding, reduces the uterine and myoma volume and thus can avoid blood transfusion and hysterectomy in a lot of symptomatic myoma cases.

KEYWORDS:

Anti-progesterone; medical treatment; mifepristone; myoma

PMID:
23833529
[PubMed]
PMCID:
PMC3702060
Free PMC Article
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