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1: Biochem Biophys Res Commun. 1990 Jul 31;170(2):951-6.Click here to read Links

Isolation and analysis of the human MEKA gene encoding a retina-specific protein.

Watanabe Y, Kawasaki K, Miki N, Kuo CH.

Department of Pharmacology, Kanazawa University, Japan.

We have isolated and sequenced a human gene encoding photoreceptor cell-specific MEKA protein. The protein coding region was separated into three exons, which encoded 246 amino acid residues with a molecular weight of 28,311. The coding region of the human gene exhibited the homologies of 90.7% nucleotides and 88.5% amino acids with those of the bovine cDNA. Southern blot analysis revealed that the human MEKA gene has a single copy number. However, the anti-bovine MEKA stained both rod and cone photoreceptor cells in the human retina.

PMID: 2383274 [PubMed - indexed for MEDLINE]