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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):719-22. doi: 10.1107/S1744309113014036. Epub 2013 Jun 27.

Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii.

Author information

  • 1National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563-8577, Japan. nakamura-t@aist.go.jp

Abstract

The crystal structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii (PhPrx) was determined at a resolution of 2.25 Å. The overall structure was a ring-type decamer consisting of five homodimers. Citrate, which was included in the crystallization conditions, was bound to the peroxidatic cysteine of the active site, with two O atoms of the carboxyl group mimicking those of the substrate hydrogen peroxide. PhPrx lacked the C-terminal tail that forms a 32-residue extension of the protein in the homologous peroxiredoxin from Aeropyrum pernix (ApPrx).

KEYWORDS:

Pyrococcus horikoshii; peroxiredoxins

PMID:
23832195
[PubMed - indexed for MEDLINE]
PMCID:
PMC3702312
[Available on 2015/7/1]
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