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Immunol Allergy Clin North Am. 2013 Aug;33(3):313-28, vii. doi: 10.1016/j.iac.2013.02.003. Epub 2013 Mar 29.

Role of cells and mediators in exercise-induced bronchoconstriction.

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  • 1Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, 1959 NE Pacific Street, Box 356522, Seattle, WA 98195-6522, USA.


A susceptible group of subjects with asthma develops airflow obstruction in response to the transfer of water out of the airways during exercise. The transfer of water or the challenge with a hypertonic solution serves as a strong stimulus to the airway epithelium. Susceptible subjects have epithelial shedding into the airway lumen, and airway inflammation that leads to the overproduction of leukotrienes and other eicosanoids following exercise challenge. The sensory nerves of the airways may serve as a critical link that mediates the effect of eicosanoids, leading to bronchoconstriction and mucus production in response to exercise challenge.

Copyright © 2013 Elsevier Inc. All rights reserved.


Asthma; Eicosanoid; Eosinophil; Exercise-induced bronchoconstriction; Leukotriene; Mast cell; Phospholipase; Prostaglandin

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