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Cell. 2013 Jul 3;154(1):26-46. doi: 10.1016/j.cell.2013.06.020.

lincRNAs: genomics, evolution, and mechanisms.

Author information

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Abstract

Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and other cellular processes. This Review outlines the emerging understanding of lincRNAs in vertebrate animals, with emphases on how they are being identified and current conclusions and questions regarding their genomics, evolution and mechanisms of action.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23827673
[PubMed - indexed for MEDLINE]
PMCID:
PMC3924787
Free PMC Article

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