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Leuk Res. 2013 Sep;37(9):1027-34. doi: 10.1016/j.leukres.2013.06.010. Epub 2013 Jul 1.

Early T-cell precursor leukemia/lymphoma in adults and children.

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  • 1Department of Pathology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.

Abstract

Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR=4.08, p=0.127, and children, HR=11.63, p=0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

ALL; Acute leukemia; Adults; Children; Early T-cell precursors; Leukemia; Lymphoblastic; Lymphoma; Prognosis

PMID:
23827350
[PubMed - indexed for MEDLINE]
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