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Dermatol Clin. 2013 Jul;31(3):445-60. doi: 10.1016/j.det.2013.04.009. Epub 2013 Jun 14.

Psoriasis as autoinflammatory disease.

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  • 1Immunology, Global Medical Affairs, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA. bejarano.0214@yahoo.com

Abstract

This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined features, and an associated or concomitant systemic inflammatory state that involves a multifactorial cellular and molecular network, transforming the old perception of psoriasis as a localized autoimmune skin disease, to one of psoriasis as a systemic inflammatory disease with autoinflammatory features and severe associated comorbid conditions.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Autoinflammatory disease; Cytokines; Genetics; Immunopathogenesis; Inflammasome; Psoriasis; TH cells; TNF-α

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