Format

Send to:

Choose Destination
See comment in PubMed Commons below
Dermatol Clin. 2013 Jul;31(3):437-44. doi: 10.1016/j.det.2013.04.008.

Role of interleukin 1 in atopic dermatitis.

Author information

  • 1Department of Medicine, Baylor University Hospital and Texas A&M Medical School, 3500 Gaston Avenue, Dallas, TX 75246, USA.

Abstract

Interleukin-1 (IL-1) is a potent inflammatory cytokine that plays a central role in the innate immune response. IL-1 mediates the acute phase of inflammation by inducing local and systemic responses, such as pain sensitivity, fever, vasodilation, and hypotension. It also promotes the expression of adhesion molecules on endothelial cells, which allows the infiltration of inflammatory and immunocompetent cells into the tissues. The release of IL-1 from the epidermis after activation is a primary event that promotes inflammatory skin conditions through the induction of various cytokines, proinflammatory mediators, and adhesion molecules.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Atopic dermatitis; Cytokines; Eczema; Inflammasome; Interleukin 1; Mononuclear cells; Neutrophils; T cells

PMID:
23827246
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk