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J Thorac Dis. 2013 Jun;5(3):298-301. doi: 10.3978/j.issn.2072-1439.2013.02.01.

Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma.

Author information

  • 1State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;

Abstract

A lower responsiveness to leukotriene D4 (LTD4) or higher LTD4/[methacholine (MCh)] potency ratio might suggest preferable outcomes of short-term montelukast monotherapy in terms of airway inflammation and lung function in asthmatic patients.

KEYWORDS:

Asthma; leukotriene D4 (LTD4); leukotriene-responsive; leukotriene-unresponsive; methacholine (MCh); montelukast

PMID:
23825762
[PubMed]
PMCID:
PMC3698267
Free PMC Article
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