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Nervenarzt. 2013 Aug;84(8):943-8. doi: 10.1007/s00115-013-3753-4.

[Possible applications of new stem cell sources in neurology].

[Article in German]

Author information

  • 1Bereich Neurodegenerative Erkrankungen, Klinik und Poliklinik für Neurologie, Technische Universität Dresden, Dresden, Deutschland.

Abstract

Stem cells provide broad possibilities in modern science and medicine. This counts not only for investigations of developmental aspects but also for cell-based therapies, pharmacotoxicological testing and improvements in personalized medicine. The recent described techniques of induced pluripotent stem cells, directly induced neural stem cells and directly induced neurons are a major step forward by providing new possibilities for research on neurological diseases. Nevertheless, a variety of questions remain open regarding stem cell-based therapeutic strategies including tumorigenicity and phenotypical stability in the receptor brain. The major hope is that the new stem cell-based neural cell systems will help to understand the pathophysiology of neurodegenerative diseases. The future will show whether and how stem cells will lead to successful restorative therapies and/or to suitable cell models for neurological diseases.

PMID:
23821289
[PubMed - indexed for MEDLINE]
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