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Autophagy. 2013 Aug;9(8):1251-2. doi: 10.4161/auto.25470. Epub 2013 Jun 25.

A genetic model with specifically impaired autophagosome-lysosome fusion.

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  • 1Department of Anatomy, Cell and Developmental Biology; Eotvos Lorand University; Budapest, Hungary.

Abstract

Yeast studies identified the evolutionarily conserved core ATG genes responsible for autophagosome formation. However, the SNARE-dependent machinery involved in autophagosome fusion with the vacuole in yeast is not conserved. We recently reported that the SNARE complex consisting of Syx17 (Syntaxin 17), ubisnap (SNAP-29) and Vamp7 is required for the fusion of autophagosomes with late endosomes and lysosomes in Drosophila. Syx17 mutant flies are viable but exhibit neuronal dysfunction, locomotion defects and premature death. These data point to the critical role of autophagosome clearance in organismal homeodynamics.

KEYWORDS:

Drosophila; SNARE; Syntaxin 17; Vamp7; autophagosome; autophagy; lysosome; neurodegeneration; ubisnap/SNAP-29

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PMID:
23819962
[PubMed - indexed for MEDLINE]
PMCID:
PMC3748198
Free PMC Article
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