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J BUON. 2013 Apr-Jun;18(2):413-9.

The association of hematologic parameters on the prognosis of patients with metastatic renal cell carcinoma.

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  • 1Department of Medical Oncology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Ismir, Turkey.

Abstract

PURPOSE:

Metastatic renal cell carcinoma (mRCC) bears a poor prognosis. We investigated the prognostic significance of some hematologic parameters of patients with mRCC.

METHODS:

We retrospectively reviewed the records of 53 patients with mRCC . The mean follow up time was 34 months (range 5-142).We assessed the prognostic value of hematologic parameters (leukocytes ,neutrophils, lymphocytes, platelets, neutrophil to lymphocyte ratio/NLR, platelet to lymphocyte ratio/PLR), and other clinical parameters with univariate and multivariate analysis.

RESULTS:

Memorial Sloan-Kettering Cancer Center (MSKCC) risk group , lung metastases, sunitinib treatment, lymphocyte count, NLR, and anemia significantly correlated with median overall survival (OS) on univariate analysis. The median OS in patients with a NLR < 3.4 was 32.2 months , significantly higher than the 13.9 months in patients with a ratio ≥ 3.4 (p = 0.006). Multivariate analysis revealed that MSKCC risk group and the NLR were independent predictors of OS.

CONCLUSION:

Hematologic parameters may be associated with OS in mRCC. However, further studies are needed to establish their routine use.

PMID:
23818354
[PubMed - indexed for MEDLINE]
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