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BMJ Case Rep. 2013 Jun 21;2013. pii: bcr2013009820. doi: 10.1136/bcr-2013-009820.

Successful treatment of pain in melorheostosis with zoledronate, with improvement on bone scintigraphy.

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  • 1Department of Medicine, Hadj Lakhdar University, Batna, Algeria.


Melorheostosis is a very rare sclerosing bone disorder that involves frequently one limb. It may be asymptomatic, but pain and limb deformity may occur and can be very debilitating. Different reports have indicated efficacy of bisphosphonates (pamidronate and etidronate) on symptoms. We report an adult patient with a very painful melorheostosis, who  improved after treatment with zoledronate, either on symptoms or on bone scans.

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