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Fitoterapia. 2013 Oct;90:14-9. doi: 10.1016/j.fitote.2013.06.014. Epub 2013 Jun 27.

Triterpene saponins from Tabellae Clinopodii.

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  • 1Ahhui University of Traditional Chinese Medicine, Hefei 230031, Anhui province, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

Abstract

Three new triterpene saponins, named Clinoposaponin A, Clinoposaponin B, and Clinoposaponin C along with three known triterpene saponins were isolated from the Tabellae Clinopodii. The structures of these compounds were elucidated by means of various spectroscopic analyses. All of the isolated compounds were tested against Hela, HCT-8, AGS, and MCF-7 human cancer cell lines and showed moderate cytotoxic activities with IC₅₀ values between 4.1 and 19.7 μM.

© 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Clinopodium; Cytotoxic activities; Saponins; Tabellae Clinopodii

PMID:
23811431
[PubMed - indexed for MEDLINE]
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