Effect of basal metabolic rate on the bone mineral density in middle to old age women in Taiwan

Background: Basal metabolic rate (BMR) reflects a combination of cardiopulmonary function and lean body mass resulting from regular physical activity. Though many studies have examined the relationships between bone mineral density (BMD) and body composition, little is known regarding the relationship between BMD and BMR.

Objective: The purpose of this study was to investigate the relationship between BMR, anthropometric parameters, body composition and BMD in postmenopausal women in Taiwan.

Methods: Two hundred and eighty-nine women between the ages of 40 and 80 years were included in this cross-sectional study. The following parameters were assessed: height, body weight, total body fat (TBF), BMR, waist-to-hip ratio, grip strength, and back strength. Differences in all variables between osteoporotic and non-osteoporotic women (categorized according to decades in age) were calculated using a one-way analysis of variance (ANOVA) and a Bonferroni post-hoc test. Multiple linear regression with a backward stepwise approach was performed to evaluate the relationship between these measurements and BMD.

Results: Among women over 50 years of age, those who were non-osteoporotic had higher BMR, BMI, and body fat by comparison to their osteoporotic counterparts (p<0.05 for all). Multiple linear regression revealed that BMR and body fat significantly predicted BMD of the femoral neck (adjusted beta coefficients of 0.304 and 0.190, respectively; p<0.05 for both). BMR and body fat also predicted an increased vertebral BMD (adjusted beta coefficients of 0.310 and 0.141, respectively; p<0.05 for both).

Conclusion: BMR is closely associated with BMD in elderly persons, and may be a novel target for interventions aimed at preventing the age-related decline in BMD.