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Tetrahedron. 2013 Jul 8;69(27-28):5744-5750.

Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas.

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  • 1Department of Chemistry, University of Utah, Salt Lake City, UT 84112, United States.


Cationic Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of dihydropyrimidines which have found use as nucleotide exchange factor inhibitors.


ARF 6; Rhodium catalysis; dihydropyrimidone; heterocycle; hydroamination

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