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Cornea. 2013 Jun 25. [Epub ahead of print]

Topography-Based Keratoconus Regression.

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  • 1*Vardinoyiannion Eye Institute of Crete, Department of Cornea, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; ‚ĆCornea and Refractive Services, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL; and ‚Ä°Faculty of Medicine and Health Sciences, An-Najah National University, Na-blus, Palestine.



To report 3 cases of keratoconic patients who had progressive corneal topographic flattening during a 2-year follow-up period.


Case series.


Three patients with bilateral keratoconus, each operated for advanced keratoconus in one of their eyes, were observed for possible progression of the disorder for a period of 2 years. During the 2-year follow-up period, topographic examination showed progressive corneal flattening in the nonoperated eye. Mean keratometry decreased in all patients, whereas topography showed significant flattening at the apex of the cone. Best-spectacle-corrected visual acuity increased in one of the patients, whereas the others had stable uncorrected and best-spectacle-corrected visual acuity during the follow-up period. All patients had positive family medical history for diabetes mellitus, but none of them was diabetic.


This is the first report of topography-based keratoconus regression during a 2-year follow-up period.

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