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Indian J Med Sci. 2012 May-Jun;66(5-6):136-40. doi: 10.4103/0019-5359.114200.

MTRR A66G polymorphism among two caste groups of Uttar Pradesh (India).

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  • 1Department of Biotechnology, Human Molecular Genetics Laboratory, VBS Purvanchal University, Jaunpur, Uttar Pradesh, India.

Abstract

OBJECTIVE:

This study was aimed to evaluate the Methionine synthase reductase (MTRR) A66G mutation in Yadav and Scheduled Caste (SC) population of Uttar Pradesh.

MATERIALS AND METHODS:

Blood samples were collected from 100 subjects after taking informed written consent and PCR-RFLP method was used for the analysis of A66G mutation. After NdeI digestion, 66-bp amplicon of normal allele was cut into 22- and 44-bp long fragments, whereas mutant G allele was not digested.

RESULTS:

Frequencies of genotypes in Yadav population AA, AG, and GG were 12%, 60%, and 28%, respectively, and in SC population, genotypic frequencies were 12% (AA), 52% (AG), and 36% (GG).

CONCLUSION:

MTRR gene A66G mutation is found to be polymorphic in both the target populations with G allele frequencies being 0.58 for Yadav and 0.62 for Scheduled Caste.

PMID:
23806987
[PubMed - indexed for MEDLINE]
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